Mustafi started for Germany during their World Cup qualifying win over Azerbaijan last Sunday night but was forced off in the first half after pulling-up clutching his thigh.
At his pre-match press conference ahead of the trip to Watford, manager Arsene Wenger has now revealed that the centre-back could be missing until the end of November.
The Cottagers, who are 10/11 (1.91) favourites to beat the Lilywhites, are unbeaten in five meetings with Preston and won back-to-back matches before the global break, so they go into the game in strong form and have a great chance of doing their bit for the treble.
The former Schalke 04 man has made six appearances in all competitions during the current campaign.
"Koscielny has a definite final test tomorrow". "At the moment he is not available".
Summer signing Sead Kolasinac is a doubt for the weekend after picking up a hip problem while playing for Bosnia although Laurent Koscielny could play a part and he is set for a fitness test on Friday.
"Jack is in the best form I've seen him in for a long time", Wenger said. "I am more concerned that yesterday afternoon I watched the whole game Brazil against Chile to see how hard the game was and I must say he got some special treatment in this game".
Chelsea and Arsenal both have very winnable away games in the Premier League, while Fulham will fancy their chances against PNE, so 7/2 (4.50) with dabblebet on the enhanced treble, boosted from 3/1 (4.0), could well prove to be a gift for punters.
"We will assess Sanchez when he comes back, I watched the Brazil game and he got some special treatment in that game".
"That is my understanding (that he wants to stay)". The player looks happy. Arsenal are fifth on 13 points from seven games.
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